“Altered amygdalar resting-state connectivity in depression is explained by both genes and environment”.
Córdova-Palomera A, Tornador C, Falcón C, Bargalló N, Nenadic I, Deco G, Fañanás L. Hum Brain Mapp.
Recent findings indicate that alterations of the amygdalar resting-state fMRI connectivity play an important role in the etiology of depression. While both depression and resting-state brain activity are shaped by genes and environment, the relative contribution of genetic and environmental factors mediating the relationship between amygdalar resting-state connectivity and depression remain largely unexplored. The present study analyzed the influence of genes and environment on amygdalar resting-state fMRI connectivity, in relation to depression risk.
Results using both methods indicate that depression risk is increased by environmental factors altering amygdalar connectivity. When analyzing the analytic components of the BOLD fMRI time-series, genetic factors altering the amygdala neural activity at rest show an important contribution to depression risk. Overall, these findings show that both genes and environment modify different patterns the amygdala resting-state connectivity to increase depression risk. The genetic relationship between amygdalar connectivity and depression may be better elicited by examining analytic components of the brain resting-state BOLD fMRI signals..